Ijeli ye-sodium ye-hyaluronate ye-Cross-Linked ukwenzela utyando


Iinkcukacha zeMveliso

Iithegi zeMveliso

Ukuveliswa kwangoku kuhambelana nejeli ye-sodium hyaluronate edibeneyo ye-tissue filler yotyando lweplastiki kunye nendlela yokuyilungisa.Isisombululo se-alkaline se-sodium hyaluronate siphendula kunye ne-alkane ye-chain ende eneqela le-epoxy kunye ne-agent edibanisayo edibanisa iqela le-epoxy kwiiyure ze-2˜5 kwi-35 ° C.˜50 ° C. ukuvelisa i-hyaluronate ye-sodium edibeneyo, emva koko ihlanjwe, ijeli kwaye inzalo, ukulungiselela ijeli.Phakathi kwazo, umlinganiselo we-molar we-sodium hyaluronate: i-agent edibanisa i-cross-link equkethe iqela le-epoxy: i-alkane chain chain equkethe iqela le-epoxy yi-10: 4˜1: 1˜4;inani lee-athom zekhabhoni zealkane chain ende equlathe iqela le-epoxy yi-6 ukuya kwe-18. Ijeli elungiselelwe kwimveliso yangoku, ngakwelinye icala, iyakwandisa ngokufanelekileyo ukuxhathisa kwi-enzymolysis ukuze ibe nozinzo ngakumbi, kwaye kwelinye icala, igcine i-biocompatibility egqwesileyo ye-sodium hyaluronate ngaphandle kokuchaphazela ukutofwa kwayo.

Ijeli ye-hyaluronate yesodium edibeneyo yotyando lweplastiki yotyando kunye nendlela yokulungiselela:

Ukuveliswa kuhambelana nendlela yokulungiselela ijeli ye-hyaluronate yesodium edityanisiweyo yotyando lweplastiki yotyando, oluphawulwa ngokubandakanya la manyathelo alandelayo:
(1) I-sodium hyaluronate powder eyomileyo yachithwa kwi-10?wt%~20?Isisombululo esixubileyo esine-wt% ye-sodium hydroxide isisombululo se-aqueous kunye ne-acetone yayisetyenziselwa ukufumana i-sodium hyaluronate basic suspension, kunye ne-agent ye-crosslinking 1,4?I-Butanediol diglycidyl ether BDDE ixutywe ngokulinganayo ukufumana izinto zokusabela, ukuze uqalise ukusabela ukuvelisa i-hyaluronate ye-sodium edibeneyo;Phantsi kwemeko evuselelayo, ukusabela kugqitywe emva kokuba izinto zokusabela zigcinwe kwi-35 ℃ ~ 50 ℃ kwiiyure ze-5 ~ 8, kunye nexabiso le-pH yezinto ezixubeneyo eziqinileyo emva kokuba i-reaction ilungelelaniswe kwi-7 kunye ne-hydrochloric acid egxininisiweyo;Apho i-concentration ye-sodium hyaluronate kwi-reaction material yi-2?I-Wt% ~ 5wt%, umlinganiselo we-mass of crosslinking agent kwi-sodium hyaluronate yi (1: 1.3) ~ (1: 1.8);
(2) Hluza umxube oqinileyo kunye nolwelo lwe-pH = 7 emva kokusabela ukususa ulwelo.Izinto eziseleyo zihlanjwe nge-acetone ukuya kwi-GC?I-MS ukufumana umxholo weBDDE ngaphantsi kwe-2ppm.Izinto eziseleyo ziquka umgubo omhlophe kunye gel elubala, kwaye ke izinto ezomisiweyo vacuum zomisiwe ukufumana amanzi-ayinyibilikiyo umgubo omhlophe owomileyo, ezizezi, cross linked sodium hyaluronate powder.
(3) Ukuhluzwa kunye nokwahlula umgubo we-sodium hyaluronate odibeneyo ofunyenwe ngokumisa nge-vacuum kwinqanaba ② kunye nokuqokelela umgubo we-sieved;
(4) Ukongeza amanzi ahlanjululweyo kwi-powder sieved eqokelelwe kwisinyathelo sesi-3, ukwenzela ukuba i-sodium hyaluronate powder idumbe ngokupheleleyo kwaye ihlanjululwe kwiiyure ze-6 ~ 10 kwiqondo lokushisa eliphakathi ukusuka kwi-15 ukuya kwi-35 degrees, kwaye i-gel particles ziqokelelwa. Fumana ijeli ye-hyaluronate ye-sodium edibeneyo.
(5) I-isotonic ye-PBS buffer yongezwa kwi-gel eqokelelwe kwinqanaba le-4 kwaye yahlanjululwa kwiiyure ze-6 ~ 10 kwiqondo lokushisa eliphakathi ukusuka kwi-15 ukuya kwi-35 degrees.Emva kokucoca, i-PBS yasuswa kwaye ijeli yaqokelelwa.Ijeli ihlolwe ngokulandelelana ngokusebenzisa inkcazo yokuqala kunye neenkcukacha zesibini zesikrini.Kufunyenwe iijeli ezi-3 ezinobungakanani obahlukeneyo, kwaye iijeli ezi-3 zacocwa kwaye zazaliswa kwisirinji elahliweyo.


  • Ngaphambili:
  • Okulandelayo:

  • Bhala umyalezo wakho apha kwaye uwuthumele kuthi